Centromere

• a region of a chromosome where it attaches to a spindle fiber during mitosis and meiosis
• the structure located at a specific site on the chromosome that holds the two chromatids together; it is the site of attachment for the spindle fibers during cell division; also called primary constriction or kinetochore
• The central portion of the chromosome to which the spindle fibers attach during mitotic and meiotic division.
• A centromere is a constricted region of a chromosome that separates it into a short arm (p) and a long arm (q). During cell division, the chromosomes first replicate so that each daughter cell receives a complete set of chromosomes. Following DNA replication, the chromosome consists of two identical structures called sister chromatids, which are joined at the centromere.