Epistasis

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  • the interaction between nonallelic genes in which one gene has a dominant effect on the expression of the other
    Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row
  • Epistasis is a circumstance where the expression of one gene is affected by the expression of one or more independently inherited genes. For example, if the expression of gene #2 depends on the expression of gene #1, but gene #1 becomes inactive, then the expression of gene #2 will not occur. In this example, gene #1 is said to be epistatic to gene #2.


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