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Holoprosencephaly is a developmental disorder that results when the forebrain of the embryo fails to divide and form the right and left halves of the brain. The disorder produces a single-lobed brain structure and severe skull and facial abnormalities. Often the deformities cause babies to die before birth. In mild cases, babies are born with near-normal brain development and facial abnormalities involving cleft lip or cleft palate.

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