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- a defined segment of DNA or RNA, usually carrying a radioactive label, used to identify a specific segment of DNA that carries the complementary base sequence
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row
- (1) A sequence of DNA or RNA, labeled or marked with a radioactive isotope, used to detect the presence of complementary nucleotide sequences. (2) A single-stranded DNA that has been radioactively labeled and is used to identify complementary sequences in genes or DNA fragments of interest.
- A probe is a single-stranded sequence of DNA or RNA used to search for its complementary sequence in a sample genome. The probe is placed into contact with the sample under conditions that allow the probe sequence to hybridize with its complementary sequence. The probe is labeled with a radioactive or chemical tag that allows its binding to be visualized. In a similar way, labeled antibodies are used to probe a sample for the presence of a specific protein.