Synthesis of Aromatic Carbonyl Thiourea PI-28 Derivatives for the Development of Radicle Elongation Inhibitor of Parasitic Weeds

Aromatic carbonyl thiourea PI-28 has been focused on as a lead compound for the developing radicle elongation inhibitors in germinating Orobanche minor dry seeds. In this study, we have synthesized PI-28 and its derivatives using commercially available phenols, 2-chloroacetamide, and aryl isothiocyanates. In this method, 2-aryloxyacetanilides, which are also attractive as bioactive compounds, were obtained as byproducts. These compounds were formed due to the loss of isothiocyanate moiety from the formed aromatic carbonyl thioureas.

https://doi.org/10.26434/chemrxiv-2022-7qm8l